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In patients that received Cy/Flu lymphodepletion and the intermediate dose of JCAR014, the data showed a promising early efficacy and side effect profile. Specifically: Overall Response rate: 82 percent (9/11) Complete Response rate: 64 percent (7/11) Severe Cytokine Release Syndrome: 9 percent (1/11) Severe neurotoxicity: 18 percent (2/11) JCAR014s hallmark is its use of a one-to-one ratio of helper (CD4+) and killer (CD8+) CAR T cells, which join forces to kill tumor cells that produce CD19, a molecule found on the surface of many blood cancer cells, including lymphoma and leukemia. By controlling the mixture of T cells that patients receive, the researchers can see relationships between cell doses and patient outcomes that were previously elusive. The data also suggest that with a defined one-to-one composition of cells, efficacy of treatment is increased, while toxic side effects are minimized. With the defined composition treatment, we are able to get more reproducible data about the effects of the cells both the beneficial impact against the cancer and any side effects to the patient, said Fred Hutch clinical researcher Dr. Stan Riddell , one of the senior authors of the paper, along with Dr. David Maloney . We are then able to adjust the dose to improve what we call the therapeutic index impact against the tumor, with lower toxicity to the patient. This study shows that at the right dose of CAR T cells and lymphodepletion, we can achieve very good response rates for NHL patients who have no other treatment options, said Dr. Cameron Turtle , an immunotherapy researcher at Fred Hutch and one of the study leaders.
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